Two sample MR report
ELP5_Monocyte (Mono) against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 12 | 0.0019506 | 0.0746660 | 0.9796720 |
| Weighted median | 12 | 0.0387306 | 0.0090352 | 0.0000181 |
| Inverse variance weighted | 12 | 0.0399973 | 0.0072997 | 0.0000000 |
| Simple mode | 12 | 0.0390177 | 0.0148075 | 0.0231993 |
| Weighted mode | 12 | 0.0382044 | 0.0135895 | 0.0169288 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.4367389 | 10 | 0.9999965 |
| Inverse variance weighted | 0.6988943 | 11 | 0.9999920 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0255519 | 0.049905 | 0.6197598 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0002511 | 0 | TRUE | 0.1335791 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
